ROLE OF MAGNESIUM IN BONE HEALTH

Abstract

Mg is vital as it maintains bone health and is also beneficial for other organs of body. Many emerging studies suggest its importance in preventing and managing osteoporosis in older adults and other bone related diseases. This review examines the current and the past studies which tells us the role of magnesium in bone health including its impact on bone mineral density and bone turnover. We discuss the molecular mechanism of magnesium and its influence on hormonal pathways involved in bone remodelling through diagrams. This study highlights importance of adequate magnesium intake on overall health. Moreover, magnesium supplements have been shown to be beneficial for bone related and other body organ diseases as well. The low intake of magnesium can cause hypomagnesemia, which displays a significant outcome on bone density. The toxicity of this nutrient is rare, known as hypermagnesemia which can cause severe cardiac failure and leads towards the mineralization defects and bone loss. In diet, low intake of magnesium can contribute towards many skeletal related disorders such as Osteopenia which is related with the reduced bone mineralization. Most common diseases associated with hypomagnesemia is osteocalcin (softening of bone tissue) that further causes rickets in children. Having low magnesium levels in serum can elevate the fragility of bones and it influences osteoclast and osteoblast activity. Magnesium also contributes with stimulation of vitamin D that prevents osteoarthritis (older adults).